Xechem: Significant Progress in the Development of Its Sickle Cell Disease Drug NICOSAN/ HEMOXIN

02/17/05 -- Xechem International Inc. (OTCBB: XKEM) today announced significant progress in its development efforts for NICOSAN(TM)/ HEMOXIN(TM), a natural product extract which shows promise in the treatment of Sickle Cell Disease (SCD). Xechem has an exclusive world-wide license for the development and sale of NICOSAN(TM)/ HEMOXIN(TM) from the National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, government of Nigeria, which holds the patent.

Through its subsidiary, Xechem Pharmaceuticals Nigeria Limited, Xechem recently signed a long-term lease for a production facility on approximately 9 acres of land at nominal cost within Nigeria's scientific complex on land owned by Sheda Science and Technology Complex, Abuja, a parastatal of the Federal Ministry of Science and Technology, Abuja, Nigeria. Xechem Nigeria is in the process of expanding this into a self-sufficient four-building complex for the commercial production of NICOSAN(TM) / HEMOXIN(TM). Much of the equipment necessary for the production has been purchased or is in the process of fabrication, with a scheduled launch of the project in the second half of 2005, for sale initially in the Nigerian market.

According to Dr. Ramesh C. Pandey, Chairman & CEO of Xechem, "We are working hard to bring NICOSAN(TM) / HEMOXIN(TM) to market initially in Nigeria and subsequently in the United States and other countries. There are approximately 4,000,000 people afflicted with Sickle Cell Disease in Nigeria alone, and development of this product is a major initiative of the Nigerian government, which has shown tremendous support for our efforts. The Nigerian market alone represents potential revenue in excess of $500,000,000 for the company. Xechem was prominently mentioned several times in the state of the union address by the Nigerian President late in 2004. There still remain additional hurdles in bringing this product to market including the need to raise additional funding for the full cost of buildout, equipping and start up of the facility. A number of initiatives are presently underway to address Xechem's financing needs. The company has developed small-scale formulations, which have shown efficacy in the treatment of the disease, and must further refine and standardize this formulation for consistent production scale quantities sharing uniform active ingredients. We are encouraged that we will find the resources to overcome remaining hurdles."

About Xechem

Xechem International, Inc., is a fully integrated biopharmaceutical company focusing on anticancer, antiviral (including AIDS), antifungal and antibacterial products from natural sources including microbial and marine organisms. Some of the key areas of Xechem are development of phytopharmaceuticals and other proprietary technologies including those used in the treatment of FDA designated orphan diseases.

For further information, contact the Company or Stephen Burg at 707-425-8855.

This press release contains forward looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities and Exchange Act of 1934, as amended, which are intended to be covered by safe harbors created hereby. Such forward-looking statements involve known and unknown risks and uncertainties, including the ability of the Company to bring NICOSAN(TM) / HEMOXIN(TM) to market which is subject to numerous challenges, including the risk that it will be unable to fund the cost of such endeavor and/or dilution to existing investors in such event, the risk that it will be unable to successfully market the product at a profit once brought to market, the risks of political and currency instability in Nigeria, the risk of being able to sustain a consistent formulation of NICOSAN(TM) / HEMOXIN(TM) for commercial production and the risk of obtaining regulatory approval for the product in jurisdictions outside of Nigeria.

Source: Xechem International, Inc.