Karolinska Institutet and Affymetrix Announce Translational Medicine Strategic Alliance

02/08/05 -- Affymetrix Inc. (Nasdaq: AFFX) and Karolinska Institutet announced today that they have entered into a strategic alliance designed to improve healthcare by accelerating the translation of basic genetic research into tools for better diagnosis, prognosis, and treatment.

During the next five years the projects include genetic analyses and measurement of gene expression in patients with atherosclerosis, breast cancer, rheumatoid arthritis, asthma and dyslexia. These diseases affect a large number of patients worldwide. Systematic use of the genomic information obtained will enable development of new and better clinical methods and drugs hereby reducing mortality and improving quality of life for patients suffering from these diseases.

The Karolinska Institutet/Affymetrix Translational medicine research projects will use sufficiently large sample sizes to establish true clinical relevance of both gene expression and DNA sequence variation in key areas of unmet medical needs.

"Today we have access to a very broad range of population-based clinical materials and data, that we want to study in order to understand the importance of genetic factors for emergence and treatment of various diseases. The agreement enables us to perform these studies at an acceptable cost and we will also get access to new technology at an early stage. Our expectation is that this cooperation will help us to improve peoples health", said Professor Jan Carlstedt-Duke, dean of research at Karolinska Institutet.

"To improve human health, we need to shift the healthcare paradigm from diagnosing and treating existing diseases, to being able to predicting disease susceptibility and an individual's response to drugs," said Patrick Kelly, European Site Manager and Vice President, Affymetrix. "This is what personalized medicine is all about -- enabling clinicians to detect diseases earlier and manage them more effectively. We are excited about the potential of this agreement to move the translational medicine field forward."

Karolinska Institutet agreement is part of the Affymetrix Translational Medicine Initiative. The goal of the initiative is to bridge the gap between clinical research and application of genomics in patient care by bringing together leading clinical research institutes with advanced Affymetrix microarray technology.

Karolinska Institutet will have access to a number of new microarray technologies from Affymetrix, including the Mapping 100K. The 100K is the first in a family of products that will allow researchers at Karolinska Institutet to perform high-density genome scans and genome-wide association studies on the genetics of complex diseases.

About Affymetrix:

Affymetrix scientists invented the world's first high-density microarray in 1989 and began selling the first commercial microarray in 1994. Since then, Affymetrix GeneChip(R) technology has become the industry standard in molecular biology research. Affymetrix technology is used by the world's top pharmaceutical, diagnostic and biotechnology companies as well as leading academic, government and not-for-profit research institutes. More than 1,200 systems have been shipped around the world and nearly 3,000 peer-reviewed papers have been published using the technology. Affymetrix' patented photolithographic manufacturing process provides the most information capacity available today on an array, enabling researchers to use a whole-genome approach to analyze the relationship between genetics and health. Affymetrix is headquartered in Santa Clara, Calif., with manufacturing facilities in Sacramento, Calif., and Bedford, Mass. The company maintains important sales and marketing operations in Europe and Asia and has about 900 employees worldwide.

All statements in this press release that are not historical are "forward-looking statements" within the meaning of Section 21E of the Securities Exchange Act as amended, including statements regarding Affymetrix' "expectations," "beliefs," "hopes," "intentions," "strategies" or the like. Such statements are subject to risks and uncertainties that could cause actual results to differ materially for Affymetrix from those projected, including, but not limited to risks of the Company's ability to achieve and sustain higher levels of revenue, higher gross margins, reduced operating expenses, uncertainties relating to technological approaches, manufacturing, product development, market acceptance, personnel retention, uncertainties related to cost and pricing of Affymetrix products, dependence on collaborative partners (including uncertainties related to the outcome of the collaboration discussed in this press release), uncertainties relating to sole source suppliers, uncertainties relating to FDA and other regulatory approvals, competition, risks relating to

intellectual property of others and the uncertainties of patent protection and litigation. These and other risk factors are discussed in Affymetrix' Form 10-K for the year ended December 31, 2003 and other SEC reports, including its Quarterly Reports on Form 10-Q for subsequent quarterly periods. Affymetrix expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Affymetrix' expectations with regard thereto or any change in events, conditions, or circumstances on which any such statements are based.

NOTE: Affymetrix, the Affymetrix logo, and GeneChip are registered trademarks owned or used by Affymetrix, Inc.

About Karolinska Institutet:

KAROLINSKA INSTITUTET is Sweden's only exclusively medical university. It is also one of the largest centres of medical education and research in Europe. Research at Karolinska Institutet spans a huge area, from sub-cellular structures to societal ones; from endorphins to the environment. Karolinska Institutet collaborates internationally and nationally with healthcare and medical institutes, as well as with industry and other universities. Our mission is to improve the health of mankind through research, education and information.

Awarding the Nobel Prize in Physiology or Medicine has given Karolinska Institutet an invaluable contact network throughout the medical scientific community.

For more information about Karolinska Institutet please visit the website: www.info.ki.se.

Source: Affymetrix, Inc